Clinical Prediction of Blood Parameters Associated with Breast, Colon, Thyroid, Ovarian, and Prostate Cancer

Diagnostic Studies

DOI: https://doi.org/10.24086/cuesj.v7n2y2023.pp7-10
Keywords: Complete blood count, breast cancer, thyroid gland cancer, testicular cancer, ovarian cancer, blood parameters

Abstract

Cancer is a cellular change caused by uncontrolled cell growth and division. This disease develops from the growth of abnormal cells that have the potential to invade or spread to other parts of the body. The aim of this study was to investigate the relationship between blood parameters (e.g., Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), Haemoglobin (HGB), White Blood Cell (WBC), and Red Blood Cell (RBC)) and different types of cancer. Breast cancer, thyroid gland cancer, ovarian cancer, testicular cancer, brain tumors as well as other types of cancer are based on the cell of the tissue found on or in the body. Any of these types of cancer are associated with a variety of health issues that put the patient's life in danger. Performing the complete blood count (CBC) test prior to or after a cancer diagnosis is necessary as abnormalities in the body can cause blood component rates to either increase or decrease, depending on the type of cancer, the patient's physiological mechanism, and the structural component. Since the CBC test belongs to hematology, drawing a blood sample and putting it into the anticoagulant tube for testing were preferred. In this study, the blood components of almost all patients were normal except for a few of them which may be due to other medical and biological factors. There is a significant relationship between blood parameters and cancer types. 

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Author Biographies

Ali J. Muhialdin, Animal Production Department, College of Agricultural Engineering Sciences, University of Garmian, Kalar, Kurdistan Region, Iraq

Ali J. Muhialdin is an Assistant Lecturer at the Department of Animal Science, College of Agricultural Engineering Sciences, University of Garmian, Kalar, Kurdistan Regional, Iraq. He got his B.Sc. degree from Salahaddin University, College of Science, Department of Biology. He obtained his M.Sc. degree from the Kahramanmaras Sutu Imam University, Faculty of Medicine, Department of Medical Microbiology. His research interests are in Pathogenic Bacteria, Molecular Microbiology, and Biotechnology.

Zaenah Z. Alamri, University of Jeddah, College of Science, Department of Biology, Jeddah 21589, Saudi Arabia

Zaenah Z. Alamri is a lecturer at University of Jeddah, College of Science, Department of Biology, Jeddah 21589, Saudi Arabia. Her research interests are Biomedical Science and Biology.

Ali M. Hussein, Department of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil 44001, Kurdistan Region, Iraq

Ali M. Hussein is a Lecturer at the Department of Biomedical Sciences, College of Science, Cihan University-Erbil. He got his B.Sc. degree in Plant Science, M.Sc. degree in Bioengineering, and Ph.D. Microbiology. His research interests are in Pathogenic Bacteria, Molecular Microbiology, and Biotechnology. He is a member of the Microbiology Society journals.

Rahman K. Faraj, Department of Chemistry, College of Science, University of Garmian, Kalar, Kurdistan Region, Iraq

Rahman Karim Faraj is a Lecturer at the Department of Chemistry, College of Science, Garmian University. He got his B.Sc. degree in Biology, M.Sc. degree as well as Ph.D. in Microbiology. His research interests are in Pathogenic Bacteria, Molecular Microbiology, and Med lab examination.

Zhala B. Taha, Department of Forestry, College of Agricultural Engineering Sciences, Salahaddin University, Erbil, Kurdistan Region, Iraq

Zhala B.Taha is an Assistant Lecturer at the Department of Forestry, College of Agricultural Engineering Sciences, Salahaddin University. She got her B.Sc. degree in Forestry, M.Sc. degree in Bioengineering, and Ph.D. in Bioactive Compound. Her research interests include Active compound, medicinal plants. She is a member of Forestry Society.

Mohammed M. Hussein, Department of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil 44001, Kurdistan Region, Iraq

Mohammed M. Hussein is an Assistant Lecturer at the Department of Biomedical Sciences, College of Science, Cihan University-Erbil. He got a B.Sc. degree in Biology and M.Sc. degree in Medical Microbiology.

Zeena M. Ameen, Department of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil 44001, Kurdistan Region, Iraq

Zeena Mahmood Ameen is an Assistant Lecturer at the Department of Biomedical Sciences, College of Science, Cihan University – Erbil. She received her B. Sc. degree in English majoring in Teaching English to Speakers of Other Languages (TESOL) and M.Sc. degree in English as a Second Language.

Naz R. Majeed, Department of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil 44001, Kurdistan Region, Iraq

Naz R. Majeed is an undergraduate student studying B. Sc. in Biomedical Sciences, Department of Biomedical Sciences, College of Science, Cihan University – Erbil.     

Maryam A. Ameed Akramc, Department of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil 44001, Kurdistan Region, Iraq

Maryam A. Ameed is an undergraduate student studying B. Sc. in Biomedical Sciences. Department of Biomedical Sciences, College of Science, Cihan University – Erbil

Mohammed I. Jameel, Department of Medical Microbiology, Koya University, Kurdistan Region, Iraq.

a Lecturer teaching in the Department of Medical Microbiology, Faculty of Science and Health at Koya University, Kurdistan Region, F.R. Iraq. I have a B.Sc. degree in Biotechnology M.Sc. degree in Bioinformatics, I am a member of Science and Health center (Genome Center), I’m handling most of the molecular biology experiment; from microbial culturing and nucleic acid isolation to amplification and sequencing experiments. My research interest includes Microarray, whole genome sequencing data analysis, Metagenomics and R programming.

References

World Health Organization. Cancer Fact Sheets. World Health Organization, Geneva, 2020. Available from: https://gco.iarc.fr/today/fact-sheets-cancers [Last accessed on 2023 Jan 29].

G. Salcedo-Villanueva, A. A. Medina-Andrade, D. MorenoParamo, M. F. Golzarri, E. Moreno-Paramo, G. Y. Ortiz-Ramirez, U. Martinez-Aguilar, U. De Dios-Cuadras, M. Jimenez-Rodriguez, I. Espinosa-Soto, X. Mira-Lorenzo, J. Guzman-Cerda, A. OrozcoMoguel, C. Becerra-Revollo, L. P. Orozco-Gomez and E. Fulda. Primary cancer sites and clinical features of choroidal metastasis in Mexican patients. Clinical Ophthalmology, vol. 15, pp. 201- 209, 2021.

G. N. Sharma, R. Dave, J. Sanadya, P. Sharma and K. K. Sharma. Various types and management of breast cancer: An overview. Journal of Advanced Pharmaceutical Technology and Research, vol. 1, no. 2, pp. 109-126, 2010.

M. Xing. Molecular pathogenesis and mechanisms of thyroid cancer. Nature Reviews Cancer, vol. 13, pp. 184-199, 2013.

D. F. Schneider and H. Chen. New developments in the diagnosis and treatment of thyroid cancer. CA: A Cancer Journal for Clinicians, vol. 63, no. 6, pp. 373-394, 2013.

G. C. Jayson, E. C Kohn, H. C. Kitchener and J. A. Ledermann. Ovarian cancer. Lancet, vol. 384, no. 9951, pp. 1376-1388, 2014.

E. Lengyel. Ovarian cancer development and metastasis. The American Journal of Pathology, vol. 177, no. 3, pp. 1053-1064, 2010.

T. Hu, Z. Li, C. Y. Gao and C. H. Cho. Mechanisms of drug resistance in colon cancer and its therapeutic strategies. World Journal of Gastroenterology, vol. 22, no. 30. pp. 6876-6889, 2016.

P. Rawla. Epidemiology of prostate cancer. World Journal of Oncology, vol. 10, no. 2. pp. 63-89, 2019.

A. Rehman, M. A. Khan, T. Saba, Z. Mehmood, U. Tariq and N. Ayesha. Microscopic brain tumor detection and classification using 3D CNN and feature selection architecture. Microscopy Research and Technique, vol. 84, no. 1, pp. 133-149, 2020.

T. Saba, A. S. Mohamed, M. El-Affendi, J. Amin and M. Sharif. Brain tumor detection using fusion of hand crafted and deep learning features. Cognitive Systems Research, vol. 59, pp. 221- 230, 2020.

G. de Vries, X. Rosas-Plaza, M. A. T. M. van Vugt, J. A. Gietema and S. de Jong. Testicular cancer: Determinants of cisplatin sensitivity and novel therapeutic opportunities. Cancer Treatment Reviews, vol. 88, p. 102054, 2020.

Y. Iwamoto. Diagnosis and treatment of Ewing’s sarcoma. Japanese Journal of Clinical Oncology, vol. 37, no. 2. pp. 79-89, 2007.

J. J. Noh, M. C. Lim, M. H. Kim, Y. H. Kim, E. S. Song, S. J. Seong, D. H. Suh, J. M. Lee, C. Lee and C. H. Choi. The prognostic model of pre-treatment complete blood count (CBC) for recurrence in early cervical cancer. Journal of Clinical Medicine, vol. 9, no. 9, p. 2960, 2020.

N. H. Mahmood, P. C. Lim, S. M. Mazalan and M. A. A. Razak. Blood cells extraction using color based segmentation technique. International Journal of Life Sciences Biotechnology and Pharma Research, vol. 2, no. 2, pp. 2250-3137, 2013.

D. K. Kur, D. Thøgersen, L. Kjeldsen and L. Friis-Hansen. The HemoScreen hematology point- of-care device is suitable for rapid evaluation of acute leukemia patients. International Journal of Laboratory Hematology, vol. 43, no. 1, pp. 52-60, 2021.

M. G. Sadovsky, A. A. Feller, E. A. Martynova, D. V. Chernyaev, E. V. Semenov, E. V. Slepov and R. A Zukov. CBC effectively stratifies the patients with different types of malignant tumors. Journal of Physics: Conference Series, vol. 1679, p. 042019, 2020.

S. Yousefian, A. Moafi and M. Khalilian. The relation between end of induction minimal residual disease and different risk factors in patients with acute lymphoblastic leukemia. Iranian Journal of Pediatric Hematology and Oncology, vol. 9, no. 4, pp. 211-218, 2019.

N. Michels, C. van Aart, J. Morisse, A. Mullee and I. Huybrechts. Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies. Critical Reviews in Oncology Hematology, vol. 157, p. 103177, 2021.

A. M. Hussein, Z. B. Taha, A. G. Malek, K. A. Rasul, D. Q. Hazim, R. J. Ahmed and U. B. Mohamed. D- dimer and serum ferritin as an independent risk factor for severity in COVID-19 patients. Materials Today: Proceedings, 2021.

T. S. Salih and S. N. R. Darogha. Incidence of B-cell leukemia among Kurdish people in Erbil City. Cihan University-Erbil Scientific Journal, vol. 2, p. 2, 2017.

Published
2023-07-20
How to Cite
1.
Muhialdin A, Alamri Z, Hussein A, Faraj R, Taha Z, Hussein M, Ameen Z, Majeed N, Ameed Akramc M, Jameel M. Clinical Prediction of Blood Parameters Associated with Breast, Colon, Thyroid, Ovarian, and Prostate Cancer. cuesj [Internet]. 20Jul.2023 [cited 4May2024];7(2):7-0. Available from: https://journals.cihanuniversity.edu.iq/index.php/cuesj/article/view/943
Issue
Vol 7 No 2 (2023)
Section
Research Article

Copyright (c) 2023 Ali J. Muhialdin, Zaenah Z. Alamri, Ali M. Hussein, Rahman K. Faraj, Zhala B. Taha, Mohammed M. Hussein, Zeena M. Ameen, Naz R. Majeed, Maryam A. Ameed Akramc, Mohammed I. Jameel

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