Serum Fibroblast Growth Factors 23, Chemerin, and Vitamin D Levels in Patients with Psoriasis

Keywords: Serum fibroblast, psoriasis, fibroblast growth factor 23, chemerin, 1,25 (OH)2D

Abstract

The aim of the study was to compare the levels of fibroblast growth factor 23 (FGF23) and chemerin, as well as Vitamin D in psoriasis sufferers and healthy controls. From 2021 to 2022, ninety subjects were studied. The study comprised 45 individuals with psoriasis and 45 healthy controls. Serum fasting FGF23 and chemerin levels of the study group were examined by sandwich enzyme-linked immunosorbent assay. The results demonstrate that the mean serum FGF23 and chemerin quantities in psoriasis patients were greater than in controls, with a statistically significant. Patients with psoriasis, on the other hand, had considerably lower blood Vitamin D levels than healthy controls. These findings demonstrate that psoriatic patients have lower Vitamin D levels than healthy controls, and they add to the growing body of data linking FGF23, chemerin Vitamin D levels, and the course of psoriasis.

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Author Biographies

Shatha N. Tawfeeq, Department of Medical Microbiology, Cihan University-Erbil, Kurdistan Region, Iraq

Shatha N. Tawfeeq is an Assistant Lecturer at the Department of Medical Microbiology, College of Science, Cihan University. She got the B.Sc. degree in General Biology, the M.Sc. degree in Zoology. Her research interests are in Physiology, Endocrinology and Hematology.

Moayad M. Al Anzy, Department of Pharmaceutical Sciences, Tikrit University, Tikrit, Iraq

Moayad M. Al Anzy an Assistant Prof. at the Department of Clinical Science Laboratory, College of Pharmacy, Tikrit University. He got the B.Sc degree in in Veterinary Medicine and Surgery, the M.Sc degree in Clinical Biochemistry, the Ph.D degree in Clinical Biochemistry

Entedhar R. Sarhat, Department of Basic Science, Faculty of Medicine, Tikrit University, Tikrit, Iraq

Entedharr R. Sarhat is a Professor at the Department of Basic Science, College of Dentistry, Tikrit University. She got the B.Sc degree in Veterinary Medicine and Surgery, the M.Sc degree in Biochemistry, the Ph.D degree in Biochemistry. Dr. Entedharr is a member of Expert Committee in Iraqi Ministry of Higher Research and Scientific Research

References

S. Pal, S. Sen, I. Nath, A. Kumar and U. K. Biswas. Psoriasis, an inflammatory condition associated with oxidative stress. Asian Journal of Medical Sciences, vol. 12, no. 4, pp. 24-30, 2021.

I. Olejniczak-Staruch, M. Ciążyńska, D. Sobolewska-Sztychny, J.Narbutt, M. Skibińska and A. Lesiak. Alterations of the skin and gut microbiome in psoriasis and psoriatic arthritis. International Journal of Molecular Sciences. vol. 22, no. 8, pp. 3998, 2021.

R. K. Jha, A. Singh, P. Koundal and R. S. Ambad. Role of lipid and oxidative stress in psoriatic patients--a case control study. Journal of Evolution of Medical and Dental Sciences, vol. 10, no. 3, pp. 132-137, 2021.

V. Gangadevi, S. Thatikonda, V. Pooladanda, G. Devabattula and C. Godugu. Selenium nanoparticles produce a beneficial effect in psoriasis by reducing epidermal hyperproliferation and inflammation. Journal Nanobiotechnology. vol. 19, no. 1, pp. 1-19, 2021.

F. Ewendt, M. Feger and M. Föller. Role of fibroblast growth factor 23 (FGF23) and αKlotho in cancer. Frontiers in Cell and Developmental Biology, vol. 8, pp. 1272, 2021.

O. Tsuprykov, X. Chen, C. F. Hocher, R. Skoblo, L. Yin and B. Hocher.Why should we measure free 25 (OH) Vitamin D? The Journal of Steroid Biochemistry and Molecular Biology, vol. 180, pp. 87-104, 2018.

S. Sun, Z. Liu, J. Fang, Y. Xie and M. Zhang, J. Yang. Serum fibroblast growth factor 23 for early detection of acute kidney injury in critical illness. American Journal of Translational Research, vol. 13, no. 11, p. 12141, 2021.

L. Bär, P. Hase and M. Föller. PKC regulates the production of fibroblast growth factor 23 (FGF23). PLoS One, vol. 14, no. 3, p. e0211309, 2019.

E. R. Sarhat and N. Murtadha. Biochemical changes in chronic renal failure pre and post hemodialysis. Primary Health Care, vol. 190, pp. 1-3, 2016.

E. R. R. Sarhat, S. A. Wadi, N. Awni, N. J. Ali and T. R. Sarhat. Evaluation of vimentin and some biochemical parameters in the blood of acute myocardial infarction patients. Egyptian Journal of Chemistry, vol. 65, no. 1, pp. 1-2, 2022.

S. E. Ahmed, E. R. Sarhat, N. Awni, T. Sarhat, K. S. Abass. Altered serum marker of adipokines profile in breast cancer women. Indian Journal of Forensic Medicine and Toxicology, vol. 15, no. 3, p. 2599, 2021.

M. Sochal, J. Fichna, A. Gabryelska, R. Talar-Wojnarowska, P. Białasiewicz and E. M. Małecka-Wojciesko. Serum levels of chemerin in patients with inflammatory bowel disease as an indicator of anti-tnf treatment efficacy. Journal of Clinical Medicine, vol. 10, no. 19, p. 4615, 2021.

E. R. Sarhat, I. M. Abid, N. A. Kamel, T. R. Sarhat and K. S. Abass. Changes of serum interleukin and chemerin levels in patients with polycystic ovary syndrome. Journal of Advanced Pharmacy Education and Research, vol. 11, pp. 11-13, no. 4, 2021.

M. S. Vandikas, K. Landin-Wilhelmsen, A. Holmäng, M. Gillstedt and A. Osmancevic. High levels of serum Vitamin D-binding protein in patients with psoriasis: A case-control study and effects of ultraviolet B phototherapy. The Journal of Steroid Biochemistry and Molecular Biology, vol. 211, pp. 105895, 2021.

Y. Kuang, Y. Y. Xiao, Z. Fang, Y. Zhang, M. Shen, X. Chen, M. Chen, C. Lv and W. Zhu. Association of serum Vitamin D with psoriasis and effect modification by central obesity. Frontiers in Medicine, vol. 7, p. 236, 2020.

C. B. Langman and J. B. Cannata-Andía. Calcium in chronic kidney disease: Myths and realities. Journal of the American Society of Nephrology, vol. 5, pp. S1-S2, 2010.

H. K. Bhattarai, S. Shrestha, K. Rokka and R. Shakya. Vitamin D, calcium, parathyroid hormone, and sex steroids in bone health and effects of aging. Journal of Osteoporosis, vol. 2020, p. 9324505, 2020.

A. Kolaszko, E. Nowalany-Kozielska, P. Ceranowicz, B. Morawiec and G. J. D. M. Kubiak. The role of parathyroid hormone and Vitamin D serum concentrations in patients with cardiovascular diseases. Disease Markers, vol. 2018, pp.1-9, 2018.

J. Mäkitaipale, S. Sankari, H. Sievänen and O. Laitinen- Vapaavuori. The relationship between serum 25-hydroxyvitamin D and parathyroid hormone concentration in assessing vitamin D deficiency in pet rabbits. BMC Veterinary Research, vol. 16, no. 1, pp. 1-8, 2020.

M. S. Regaña, G. M. Ezquerra and P. U. Millet. Serum levels of parathyroid hormone and parathyroid‐related peptide in psoriasis. Acta Dermato-Venereologica, vol. 85, no. 5, 2005.

B. Zhang, A. T. Umbach, H. Chen, J. Yan, H. Fakhri, A. Fajol, M. S. Salker, D. Spichtig, A. Daryadel, C. A. Wagner, M. Föller and F. Lang. Up-regulation of FGF23 release by aldosterone. Biochemical and Biophysical Research Communications, vol. 470, no. 2, pp. 384-390, 2016.

N. Carrillo-López, P. Román-García, A. Rodríguez-Rebollar, J. L. Fernández-Martín, M. Naves-Díaz and J. B. Cannata-Andía. Indirect regulation of PTH by estrogens may require FGF23. Journal of the American Society of Nephrology, vol. 20, no. 9, pp. 2009-2017, 2009.

I. Zanoni and F. J. E. Granucci. Regulation and dysregulation of innate immunity by NFAT signaling downstream of pattern recognition receptors (PRRs). vol. 42, no. 8, pp. 1924-1931, 2012.

U. A. S. El Din, M. M. Salem and D. O. Abdulazim. Is fibroblast growth factor 23 the leading cause of increased mortality among chronic kidney disease patients? A narrative review. Journal of Advanced Research, vol. 8, no. 3, pp. 271-278, 2017.

G. Okan, A. M. Baki, E. Yorulmaz, S. Doğru-Abbasoğlu and P. Vural. Fibroblast growth factor 23 and placental growth factor in patients with psoriasis and their relation to disease severity. Annals of Clinical Laboratory Science, vol. 46, no. 2, pp. 174-179, 2016.

E. Riffat Sarhat, S. J. Khalaf and M. S. Hamad. A study of some biochemical parameters in blood serum of patients with congestive heart failure. vol. 10, no. 5, p. 412, 2019.

P. Gisondi, V. Lora, C. Bonauguri, A. Russo, G. Lippi and G. Girolomoni. Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab. British Journal of Dermatology, vol. 168, no. 4, pp. 749-755, 2013.

V. Lora, C. Bonaguri, P. Gisondi, F. Sandei, L. Battistelli, A. Russo, A. Melegari, T. Trenti and G. Lippi and G. Girolomoni. Autoantibody induction and adipokine levels in patients with psoriasis treated with infliximab. Journal of Immunology Research, vol. 56, no. 2, pp. 382-389, 2013.

Y. Xue, L. Jiang, Q. Cheng, H. Chen, Y. Yu, Y. Lin, X. Yang, N. Kong, X. Zhu, X. Xu, W. Wan and H. Zou. Adipokines in psoriatic arthritis patients: The correlations with osteoclast precursors and bone erosions. PLoS One, vol. 7, no. 10, pp. e46740, 2012.

Y. Song, X. Zhu, Z. Lin, L. Luo and D. Wen. The potential value of serum chemerin in patients with breast cancer. Scientific Reports, vol. 11, no. 1, pp. 1-6, 2021.

F. Bai, W. Zhen, Y. Dong, J. Wang, M. A. Garstka, R. Li, J. An and H. Ma. Serum levels of adipokines and cytokines in psoriasis patients: A systematic review and meta-analysis. Oncotarget, vol. 9, no. 1, p. 1266, 2018.

K. M. Chyl-Surdacka, A. Gerkowicz, J. Bartosińska, M. Kowal, J. Przepiórka-Kosińska, G. Surdacki, D. Krasowska and G. Chodorowska. Analysis of serum chemerin concentrations in psoriatic patients in relation to metabolic abnormalities. Postepy Dermolatol Alergol, vol. 36, no. 5, p. 531, 2019.

M. Maleki, Y. Nahidi, S. Azizahari, N. T. Meibodi and A. Hadianfar. Serum 25-OH Vitamin D level in psoriatic patients and comparison with control subjects, J Cutan Med Surg, vol. 20, no. 3, pp. 207-210, 2016.

L. Barrea, M. C. Savanelli, C. Di Somma, M. Napolitano, M. Megna, A. Colao and S. Savastano. Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist, Rev Endocr Metab Disord, vol. 18, no. 2, pp. 195-205, 2017.

A. Q. Hamdi, E. R. Sarhat, N. H. Ali and T. R. Sarhat. Evaluation of lipocalin-2 and visfatin, and Vitamin (D, C, and E) in serum of diabetic patients with chronic periodontitis. Indian Journal of Forensic Medicine and Toxicolog, vol. 15, no. 2, pp. 1668-1674, 2021.

A. Filoni, M. Vestita, M. Congedo, G. Giudice, S. Tafuri and D. J. M. Bonamonte, Association between psoriasis and Vitamin D: Duration of disease correlates with decreased Vitamin D serum levels: An observational case-control study. Medicine (Baltimore), vol. 97, no. 25, p. e11185, 2018.

Y. H. Lee and G. G. Song. Association between circulating 25‐hydroxyvitamin D levels and psoriasis, and correlation with disease severity: A meta-analysis. Clin Exp Dermatol, vol. 43, no. 5, pp. 529-535, 2018.

Published
2022-08-20
How to Cite
1.
Tawfeeq S, Al Anzy M, Sarhat E. Serum Fibroblast Growth Factors 23, Chemerin, and Vitamin D Levels in Patients with Psoriasis. cuesj [Internet]. 20Aug.2022 [cited 1Oct.2022];6(2):57-1. Available from: https://journals.cihanuniversity.edu.iq/index.php/cuesj/article/view/706
Section
Research Article