Comparison of Biochemical Parameters in Vaccinated and Non-vaccinated SARS-COV-2 Patients in Erbil-City
DOI:
https://doi.org/10.24086/cuesj.v8n1y2024.pp46-57Keywords:
Vaccine, bone markers, liver enzymes, biochemical, SARS-CoV-2Abstract
COVID-19 is one of the major pandemic caused by SARS-CoV-2. Vaccination is one of the methods used that reduce the spread of an infectious disease. Consequently, we aimed to measure the levels of some liver parameters (ALT, AST, ALP, TSB, LDH and Albumin), as well as bone markers (Ca, P, PTH and TSH) as marker for the severity of the disease in Non-vaccinated and Vaccinated SARS-COV-2 patients. Between November 2021 and May 2022, 130 sample of both genders (healthy and infected with COVID-19) were obtained, and divided into three major groups: healthy individuals (50), vaccinated (30) and non-vaccinated (50) group" (ages; 20-65). Our findings showed that serum ALT, ALP, LDH, significantly elevated (p < 0.01), and despite comparing patients who were not vaccinated to those who were, serum albumin considerably dropped. Moreover, serum AST and TSB moderately elevated in unvaccinated group in comparison to unvaccinated patients. Regarding bone markers, Ca and P, slightly decreased in non-vaccinated and vaccinated patients compare to healthy control group. Whereas the serum PTH and TSH significantly less in both patient groups than in control. “The optimal cut-off values for liver parameters and bone markers were determined by ROC Curve Analysis. In conclusion, vaccine plays major role in minimizing liver biomarkers in COVID-19 patients. Moreover, low concentrations of serum bone markers were associated with both vaccinated and non-vaccinated COVID-19 patients. Therefore, the bone health status of COVID patients and liver markers are helpful for the diagnosis and monitoring of disease severity in COVID‐19 patient.
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