The Protective Rolls of Taraxacum officinale against Carbone Tetrachloride Infarction in the Liver

Farhang A. Mustafa; Khabat A. Ali

doi:10.24086/cuesj.v7n1y2023.pp39-47

Farhang A. Mustafa Department of Biology, College of Education, Salahaddin University-Erbil, 44002, Erbil, Kurdistan Region, Iraq https://orcid.org/0000-0001-5008-1011
Khabat A. Ali Department of Biology, College of Education, Salahaddin University-Erbil, Kurdistan Region, Iraq. https://orcid.org/0000-0001-5008-1011

DOI: https://doi.org/10.24086/cuesj.v7n1y2023.pp39-47

Keywords: Carbon tetrachloride, hepatoprotictive effect, oxidative stress, silver nanoparticles, Taraxacum officinale

Abstract

Carbon tetrachloride (CCl4) is a liquid that is colorless, transparent, inflammable, and volatile. Its central carbon atom is surrounded by four Cl- atoms. As a result, the objective of this effort was to estimate the anti-oxidant properties of silver nanoparticles (AgNPs) made utilizing aqueous plant extracts from Taraxacum officinale leaves. A green synthesis of AgNPs using a synergistic aqueous extract from T. officinale leaves was tested against liver damage in rats caused by CCl4. The rats were randomly distributed into seven groups: Group 1: Control group, Group 2: Olive oil group, Group 3: AgNPs-treated group (100 mg/kg BW.), Group 4: AgNPs-treated group (200 mg/kg BW.), Group 5: CCl4 + Olive oil group, Group 6: (CCl4 + Olive Oil) + 100 mg/kg of AgNPs-treated group, and Group 7: (CCl4 + Olive oil) + 200 mg/kg of AgNPs-treated group one a week for 6 weeks. This study demonstrated a sustainable method for synthesizing AgNPs utilizing T. officinale leaf (TOL) extract. To characterize the synthesized T. officinale leaf-silver nanoparticles (TOL-AgNPs), various microscopic and spectroscopic methods were used. The effectiveness of the biosynthesized TOL-AgNPs against CCl4 was tested to assess their antioxidant potential. The antioxidant properties of synthetic TOL-AgNPs were also evaluated. Histopathological research showed that all groups treated with nano-extract had less severe inflammatory responses. Our findings demonstrated that AgNPs synthesized using the leaves of T. officinale possess a potential anti-oxidant activity against CCl4-induced liver injury in rats.

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Author Biographies

Farhang A. Mustafa, Department of Biology, College of Education, Salahaddin University-Erbil, 44002, Erbil, Kurdistan Region, Iraq

Farhang A. Mustafa is a teacher at Choman scientific high school, Choman Education, he got a B.Sc. degree in Biology Collage of Education, Salahaddin University (2011-2012). he is M.Sc. student at the Department of Biology, Collage of Education, Salahaddin University (2019-2020). His research interests are in antioxidant and nanoparticles.

Khabat A. Ali, Department of Biology, College of Education, Salahaddin University-Erbil, Kurdistan Region, Iraq.

Khabat A. Ali is a Prof. Dr. at the Department of Biology, College of Education, Salahaddin University. He graduated from (BSC) and was appointed to Salahaddin University / College of Education / Department of Biology and obtained a master’s degree ( MSC ) at Salahaddin University/College of Science/Department of Biology. As well as, obtained a doctorate (PhD) at the University of Mosul / College of Science / Department of Biology in the speciality of histology and embryos. His research interests are in histological, nanoparticle and herbal antioxidant research.

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