Estimation of HOMA-IR and Triglyceride-Glucose Index in Single Females with PCOS

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DOI:

https://doi.org/10.24086/cuesj.v10n1y2026.pp18-23

Keywords:

Polycystic ovarian syndrome, homeostatic model assessment for insulin resistance, triglyceride-glucose index, insulin resistance

Abstract

This study aims to estimate insulin resistance (IR) in single females with polycystic ovarian syndrome. A cross-sectional study was designed to assess the insulin hormone, blood glucose level, IR biomarker, triglyceride-glucose index, serum high-density lipoprotein, and triglyceride. The present included 45 single female participants whom a specialist gynecologist had previously diagnosed. Statistically, Females following a healthy diet showed a non-significant decrease in homeostatic model assessment for IR (HOMA-IR) and a fasting glucose-to-insulin ratio when compared with non-dieters. Regarding the menstrual cycle, the triglyceride-glucose index (a measure of IR) was considerably higher in females with irregular menstrual cycles (P ≤ 0.05) than in those with regular cycles. A significant positive (direct) correlation was observed between HOMA-IR and the triglyceride-Glucose (TyG) index among single females. This study indicated a strong positive correlation between HOMA-IR and the Triglyceride-Glucose Index among single female patients. In conclusion, a balanced diet is crucial for mitigating IR in this condition. Unusual menstruation was closely linked to poor metabolic profiles, such as increased IR and dyslipidemia.

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Author Biographies

Zahraakhan M. Taher , Department of Biomedical Sciences, College of Applied Sciences, Cihan University - Erbil

 Zahraakhan Maaroof Taher is an Assistant Lecturer with a M.Sc. degree in Clinical Biochemistry, teaching in the department of Biomedical Sciences at Cihan University-Erbil, Kurdistan Region, F.R. Iraq. Her research interest is  Clinical Biochemistry.

Bakhtawar Z. Omer , Department of Biomedical Sciences, College of Applied Sciences, Cihan University-Erbil, Erbil, Kurdistan Region, Iraq

Bakhtawar Ziad Omer is an assistant lecturer at the Department of Biomedical Sciences, College of Applied Sciences, Cihan University-Erbil, Erbil, Kurdistan Region, Iraq. Her research interest is Biomedical science.

Zheyan T. Younis, Department of Basic Science, College of Dentistry, Hawler Medical University, Erbil, Kurdistan Region, Iraq

Zheyan Tahir Younis is an Assistant Lecturer holding an M.Sc. degree in Physiology and teaching in the Department of Basic Science, College of Dentistry, Hawler Medical University, Erbil, Kurdistan Region, F.R. Iraq. Her research interest is Basic Science and Dentistry.

Dunya A. Asaad, Department of Medical Biochemical Analysis, College of Health Technology, Cihan University–Erbil, Erbil, Kurdistan Region, Iraq

Dunya Abdulqader Asaad holds a Master’s degree in Medical Biochemistry and currently serves as a Laboratory Assistant in the Department of Medical Biochemical Analysis, College of Health Technology, Cihan University–Erbil, Erbil, Kurdistan Region, F.R. Iraq.

 

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Published

2026-02-01

How to Cite

1.
Taher ZM, Omer BZ, Younis ZT, Asaad DA. Estimation of HOMA-IR and Triglyceride-Glucose Index in Single Females with PCOS. Cihan U Erbil SCI J [Internet]. 2026 Feb. 1 [cited 2026 Jun. 23];10(1):18-23. Available from: https://journals.cihanuniversity.edu.iq/index.php/cuesj/article/view/1614

Issue

Vol. 10 No. 1 (2026)

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Research Article

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Copyright (c) 2026 Zahraakhan M. Taher , Bakhtawar Z. Omer , Zheyan T. Younis, Dunya A. Asaad

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