Levels of Apelin, Endoglin, and Transforming Growth Factor Beta 1 in Iraqi Women with Polycystic Ovary Syndrome

  • Noor Alhuda K. Ibrahim Department of Basic Sciences, College of Nursing, Baghdad University, Baghdad, Iraq
  • Wasnaa J. Mohammad Department of Basic Sciences, College of Nursing, Baghdad University, Baghdad, Iraq
  • Sanan T. Abdawahab Department of Medical Laboratory Techniques, Dijlah University College, Baghdad, Iraq
Keywords: Apelin, Endoglin, Transforming growth factor beta

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in women of reproductive age. The aim of the study was to determine the level of apelin, insulin resistance (IR), transforming growth factor beta 1 (TGF-β1), and endoglin in women with polycystic ovary syndrome. Fifty PCOS patients and 40 non-PCOS infertile patients were recruited. The fasting serum levels of folliclestimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin, fasting blood glucose, insulin, and apelin at the early follicular phase were measured. Levels of apelin, LH, LH/FSH, T, and fasting insulin, as well as homeostatic model assessment of IR (HOMA-IR) in PCOS patients, were significantly higher than in the control group. Correlation analysis showed that apelin level was positively correlated with body mass index and HOMA-IR. Apelin levels and TGF-β1 were significantly increased in PCOS patients while show decrease levels of endoglin.

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Published
2020-01-17
How to Cite
Ibrahim, N. A., Mohammad, W., & Abdawahab, S. (2020). Levels of Apelin, Endoglin, and Transforming Growth Factor Beta 1 in Iraqi Women with Polycystic Ovary Syndrome. Cihan University-Erbil Scientific Journal, 4(1), 21-25. https://doi.org/10.24086/cuesj.v4n1y2020.pp21-25
Section
Research Article