Omega-3 Oil Ameliorate Histological and Ultrastructural Alterations Induced by Cadmium Chloride in Rats Testis

  • Treefa F. Ismail Department of Biology, College of Education, University of Salahaddin, Kurdistan Region, Iraq
  • Falah M. Aziz Department of Biology, College of Science, University of Salahaddin, Kurdistan Region, Iraq
Keywords: Cadmium chloride, Omega-3, Testis, Ultrastructural


Cadmium (Cd) is considered to be one of the major environmental pollutants which have potential threat to human health. Reports of declining male fertility have renewed interest in the role of environmental and occupational exposures in the etiology of human infertility. Cd exposure led to obvious degenerative changes in testicular tissue. This study was performed to investigate the Cd-induced structural effects on the testes and to evaluate the possible protective effect of omega-3 oil in adult albino rats. Thirty adult male rats were used in the present work, divided randomly into five groups, six rats in each group; the first group was considered as a control group and left without treatment except the standard rat chow and tap water. The second group was given 40 mg/L of CdCl2 in drinking water while the third group was given 60 mg/L of CdCl2 in drinking water. The fourth group was given 40 mg/L of CdCl2 in drinking water plus omega-3 oil (4 g/kg diet), while the fifth group was given 60 mg/L of CdCl2 in drinking water plus omega-3 oil (4 g/kg diet), the Cd-treated rats showed dose-dependent histological and ultrastructural alterations which have been ameliorated after exposure to omega-3 oil. The present investigation concluded that omega-3 played a protective role against Cd-induced histopathological changes in rat testis.


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How to Cite
Ismail T, Aziz F. Omega-3 Oil Ameliorate Histological and Ultrastructural Alterations Induced by Cadmium Chloride in Rats Testis. cuesj [Internet]. 17Jan.2020 [cited 5Mar.2024];4(1):62-9. Available from:
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