The Impact of Different Doses of Nickel Chloride on Some Biochemical and Histopathological Changes in the Liver of Rats
DOI:
https://doi.org/10.24086/cuesj.v9n2y2025.pp92-99Keywords:
Rat, Nickel, Liver, Apoptosis, degenerationAbstract
The present study investigated the effects of different doses of nickel chloride (NiCl₂) on biochemical markers and liver histology. Twenty-one young male rats, aged 3–4 weeks and weighing 150 - 200 g, were randomly assigned to three groups (N=7). The control group received only tap water, while the other two groups were exposed to nickel chloride at concentrations of 100 mg/kg and 150 mg/kg in their drinking water for six weeks. The results indicated no significant differences in biochemical parameters between the treated groups and the control subjects. Histological examination of liver tissues from rats exposed to nickel chloride (100 mg/kg and 150 mg/kg) revealed significant pathological changes. Observed abnormalities included cellular swelling, nuclear pyknosis, degeneration, necrosis, and blood vessel congestion, with higher doses leading to more pronounced damage. These findings suggest that nickel chloride poses a potential risk to liver health even at low concentrations and short exposure durations.
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Copyright (c) 2025 Merza H. Homady, Huda S. Bilal, Mirzan M. Omer, Sarah L. Alnuaimy, Hawta S. Khalid
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