Antibacterial and Wound Healing Assessment of Silver Nanoparticles against Multidrug-Resistant Klebsiella variicola

Abstract

The increase in antimicrobial resistance and the absence of novel antibiotic development cause problems in controlling infections for wound healing. Antibacterial properties of nanomaterials have emerged as a potentially effective approach in the pursuit of superior alternatives, nevertheless, the toxicity associated with higher concentrations has emerged as a significant obstacle. According to this study, green nanoparticle synthesis is demonstrated to be both economical and biocompatible on account of the bioactive compounds present. In the present work, silver nanoparticles prepared by using Pistacia khinjuk gum, then, nanoparticle-based cream was prepared and compared with Fusidin and Vaseline creams via assessment in vitro antibacterial and in vivo wound healing activity on Wistar albino rats infected with multi drug resistant Gram negative bacteria which was newly recorded in Iraq, namely Klebsiella variicola. The findings revealed that the application of nanoparticle cream resulted in more rapid and effective wound healing (11 days), demonstrating a significant synergistic effect in comparison to Fusidin (16 days), Vaseline (20 days), and the untreated control group rats (32 days). The results indicated that green nanoparticles proved to be a significant strategy in the fight against multidrug resistant bacteria, without any toxicity concerns.