The Effect of Hypericum perforatum Extract on Gastric Ulcer Development in Rat Models

Keywords: Gastric ulcer, antibacterial activity, Helicobacter pylori, gastrointestinal tract, peptic ulcer

Abstract

Gastric ulcer is a serious condition that results from the wearing/tearing of the stomach mucosa. A physiological equilibrium is maintained between mucosal defense and aggressive factors. In this study, the effectiveness of medicinal plants (Hypericum perforatum) in the management of gastric ulcer was compared to that of omeprazole, a well-known drug for gastric ulcer. This study involved numerous study groups of male rats comprising of the following: the first group (control group exposed to H. pylori and fed with normal animal feed), the second group (rats exposed to H. pylori and treated with two doses {of 250 mg/kg and 500 mg/kg} of aqueous H. perforatum), and the third group (rats exposed to H. pylori and treated with 20 mg/kg of omeprazole). The outcome of the study demonstrated that a high dose of H. perforatum prevents (50.65%) the development of stomach ulcers. The group treated with omeprazole revealed a formation of stomach ulcers (24.50%). A high dose of the aqueous plant extracts showed greater effectiveness in preventing gastric ulcer formation compared to the lower dosage.

Downloads

Download data is not yet available.

Author Biography

Mohammed M. Hussein, Department of Biomedical Sciences, Cihan University-Erbil, Kurdistan Region, Iraq

Mohammed M. Hussein is an Assistant Lecturer at the Department of Biomedical Sciences, College of Science, Cihan University-Erbil. He got a B.Sc. degree in Biology and M.Sc. degree in Medical Microbiology. 

References

Palamides, P., Jolaiya, T., Idowu, A., Loell, E., Onyekwere, C., Ugiagbe, R., & Carranza, M. (2020). Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome. Scientific Reports, 10(1), 1-13.

Yulizal, O. K., Lelo, A., Ilyas, S., & Raden, L. K. (2020). The effect of Channa striata extract and standard eradication regimen on asymmetric dimethylarginine in Helicobacter pylori gastritis rat model. Veterinary World, 13(8), 1605.

Mashayekhi-sardoo, H., Razavi, B. M., Ekhtiari, M., Kheradmand, N., & Imenshahidi, M. (2020). Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats. Iranian Journal of Basic Medical Sciences.

Youssef, H., & El-Mahmoudy, A. M. (2019). Evaluation of the antimicrobial potential of Punica Granatum leaves hydro-methanolic extract against selected pathogens. American Journal of Current Microbiology, 7(1), 23-33.

Belwal, T., Devkota, H. P., Singh, M. K., Sharma, R., Upadhayay, S., Joshi, C.,& Pande, V. (2019). St. John’s Wort (Hypericum perforatum). In Nonvitamin and Nonmineral Nutritional Supplements (pp. 415-432).

HOSSEINI, V. S., Afzali, N., Namaei, M. H., & Allahressani, A. (2015). Effect of water extract of Hypericum perforatum on performance, abdominal fat and blood biochemical parameters of broiler chicken.

Pedernera, A. M., Guardia, T., Calderón, C. G., Rotelli, A. E., de la Rocha, N. E., Di Genaro, S., & Pelzer, L. E. (2006). Anti-ulcerogenic and anti-inflammatory activity of the methanolic extract of Larrea divaricata Cav. in rat. Journal of ethnopharmacology, 105(3), 415-420.

Nasr, N. M., Khider, M., Metry, W., & Atallah, K. (2017). Antibacterial Activity of Lactic Acid Bacteria against Helicobacter pylori Evidence by in vivo and in vitro Studies. Int. J. Curr. Microbiol. App. Sci, 6(12), 4235-4247.

Kauffman Jr, G. L., & Grossman, M. I. (1978). Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates. Gastroenterology, 75(6), 1099-1102.

Njar, V. C., Adesanwo, J. K., & Raji, Y. (1995). Methyl angolensate: the antiulcer agent of the stem bark of Entandrophragma angolense. Planta medica, 61(01), 91-92.

Zdunić, G., Gođevac, D., Milenković, M., Vučićević, D., Šavikin, K., Menković, N., & Petrović, S. (2009). Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. Phytotherapy Research, 23(11), 1559-1564.

Walan, A., Bader, J. P., Classen, M., Lamers, C. B., Piper, D. W., Rutgersson, K., & Eriksson, S. (1989). Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. New England Journal of Medicine, 320(2), 69-75.

Saeed AL-Wajeeh, N., Halabi, M. F., Hajrezaie, M., M. Dhiyaaldeen, S., Abdulaziz Bardi, D., M. Salama, S., & Mohd Ali, H. (2016). The gastroprotective effect of vitex pubescens leaf extract against ethanol-provoked gastric mucosal damage in sprague-dawley rats. Plos one, 11(9), e0157431.

Seyhan, N. (2020). Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats. Evidence-Based Complementary and Alternative Medicine, 2020.

Seyis, F., Yurteri, E., Özcan, A., & Cirak, C. (2020). Altitudinal impacts on chemical content and composition of Hypericum perforatum, a prominent medicinal herb. South African Journal of Botany, 135, 391-403.

Published
2023-05-20
How to Cite
1.
Hussein M. The Effect of Hypericum perforatum Extract on Gastric Ulcer Development in Rat Models. cuesj [Internet]. 20May2023 [cited 27May2024];7(1):48-1. Available from: https://journals.cihanuniversity.edu.iq/index.php/cuesj/article/view/902
Section
Research Article